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Description from hodgdonpowders.com:
This was an unnamed spherical rifle propellant when Bruce “B.E.” Hodgdon first used it. When a 38.0 grain charge behind a 52 grain bullet gave one hole groups from his 22-caliber wildcat (now called the 22-250), he appropriately named the powder H380. H380 is also a superb performer in the 220 Swift, 243, 257 Roberts and other fine varmint cartridges.